what muscle disorder causes kidneys to shut down

Rhabdomyolysis occurs when muscle fibers damaged past affliction, injury, or toxic substances break downwardly and release their contents into the bloodstream. Severe affliction can cause acute kidney injury.

• Mutual causes include musculus injury and impaired claret flow in damaged tissue, drugs, toxic substances, and infections.

• Less common causes include electrolyte imbalances, endocrine and genetic disorders, farthermost exercise, and extremes in body temperature.

• Symptoms can include muscle pain, weakness, and reddish-chocolate-brown (or tea-colored) urine, just near people exercise not have all of these symptoms.

• Diagnosis is with blood and urine tests.

Normal skeletal musculus part requires proper exchange of electrolytes (electrically charged minerals such as sodium and potassium) beyond muscle cells (myocytes). This exchange allows the cells to adequately metabolize adenosine triphosphate (ATP), a molecule necessary for transporting free energy inside cells and powering the trunk'due south functions.

In rhabdomyolysis the processes that back up the normal functioning of skeletal muscle are disrupted, so that myocytes interruption downward and release some of their contents into the bloodstream, including

• Creatine kinase (CK), a protein that rises when muscle is damaged

• Myoglobin, an iron-containing protein that transports and stores oxygen in myocytes

• Electrolytes

Any form of musculus impairment can upshot in rhabdomyolysis. The most common causes of that impairment include

• Some drugs and toxic substances

• Infection (for example, influenza A or B Flu (Flu) Influenza (flu) is a viral infection of the lungs and airways with one of the influenza viruses. It causes a fever, runny nose, sore throat, cough, headache, muscle aches (myalgias), and a full general... read more virus, coxsackievirus Overview of Enterovirus Infections Enterovirus infections touch many parts of the trunk and may be caused by any of several different strains of enterovirus. Enterovirus infections are acquired past many different viruses. Symptoms... read more , or the bacteria Staphylococcus aureus Staphylococcus aureus Infections Staphylococcus aureus is the most unsafe of all of the many mutual staphylococcal bacteria. These gram-positive, sphere-shaped (coccal) bacteria (run across effigy ) frequently cause peel infections... read more than )

Some drugs and toxic substances (for instance, statins Lipid-Lowering Drugs ) can cause straight muscle damage. Other drugs and toxic substances raise levels of drugs that could damage muscle (for example, drug interactions involving antibiotics Overview of Antibiotics Antibiotics are drugs used to treat bacterial infections. They are ineffective against viral infections and nearly other infections. Antibiotics either kill microorganisms or stop them from reproducing... read more ). Still other drugs and toxic substances impairment muscle indirectly by restricting blood supply to those muscles. For example, people who are sedated and immobile afterward taking drugs such every bit antianxiety agents Antianxiety and Sedative Drugs Antianxiety and sedative drugs are prescription drugs used to relieve feet and/or assist with sleep, but their use tin can effect in dependency and a substance utilize disorder. Using prescription... read more than , antipsychotics Antipsychotic Drugs Psychosis refers to symptoms such equally delusions, hallucinations, disorganized thinking and voice communication, and bizarre and inappropriate motor behavior that betoken loss of contact with reality. A number... read more , cocaine Cocaine Cocaine is an addictive stimulant drug made from leaves of the coca constitute. Cocaine is a strong stimulant that increases alacrity, causes euphoria, and makes people feel powerful. Loftier doses... read more than , amphetamines Amphetamines Amphetamines are stimulant drugs that are used to treat sure medical conditions, but are besides subject to corruption. Amphetamines increase alertness, enhance concrete performance, and produce... read more than , or booze Booze Booze (ethanol) is a depressant. Consuming large amounts rapidly or regularly can crusade health problems, including organ damage, coma, and death. Genetics and personal characteristics may... read more may stay in the same position for hours, which can atomic number 82 to pinch and damage of certain muscles and the blood vessels to those muscles.

Less mutual causes of rhabdomyolysis include

• Farthermost exercise

• Prolonged bed rest

The three classic symptoms of rhabdomyolysis are muscle hurting, weakness, and cherry-red-brown or tea-colored urine (acquired by the high levels of the red-pigmented poly peptide myoglobin that is dumped into the blood). However, this trio of symptoms is present in less than 10% of all people with rhabdomyolysis.

The symptoms of rhabdomyolysis vary, and about 50% of people have no muscle complaints at all. When present, muscle pain tends to bear upon the shoulders, thighs, lower back, and calves.

At a loftier concentration, myoglobin excreted into the urine (myoglobinuria) changes the color of the urine to red or brown and can be confirmed with a urine exam. However, a person can have rhabdomyolysis without also having discolored urine.

Other signs and symptoms depend on the crusade of the original musculus injury as well as on the complications of that injury (for example, fever in people with infection or changes in alertness in intoxicated people).

• A doctor's evaluation

• Claret and urine tests

Doctors suspect rhabdomyolysis based on symptoms. The diagnosis is confirmed past blood tests.

Sometimes additional laboratory testing to detect myoglobin in the urine is done to confirm the diagnosis.

• Handling of underlying cause

• Treatment of complications

In general, treatment is aimed at the cause and any complications of rhabdomyolysis.

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